TY - CHAP A1 - Jia Guo A2 - Jianglin Zhang ED1 - Xianquan Zhan Y1 - 2020-12-09 PY - 2020 T1 - Ubiquitination and Deubiquitination in Melanoma Research and Clinically Relevant Outcomes N2 - The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases. BT - Ubiquitin SP - Ch. 4 UR - https://doi.org/10.5772/intechopen.94512 DO - 10.5772/intechopen.94512 SN - 978-1-83880-841-9 PB - IntechOpen CY - Rijeka Y2 - 2021-03-01 ER -