TY - CHAP A1 - Alejando Córdova Izquierdo A2 - Adrian Emmanuel Iglesias Reyes A3 - Alda Roció Ortiz Muñiz A4 - María de Lourdes Juárez Mosqueda A5 - Jesús Alberto Guevara González A6 - Juan Eulogio Guerra Liera A7 - Gustavo Ruiz Lang A8 - Rubén Huerta Crispín A9 - Abel E. Villa Mancera A10 - Pedro Sánchez Aparico A11 - Raúl Sánchez Sánchez ED1 - Margarete Dulce Bagatini Y1 - 2020-08-26 PY - 2020 T1 - Effect of Oxidative Stress on Sperm Cells N2 - The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system. BT - Glutathione System and Oxidative Stress in Health and Disease SP - Ch. 6 UR - https://doi.org/10.5772/intechopen.88499 DO - 10.5772/intechopen.88499 SN - 978-1-83880-126-7 PB - IntechOpen CY - Rijeka Y2 - 2020-10-29 ER -