TY - CHAP A1 - Norihide Fukushima A2 - Motohiro Kawauchi A3 - Francois Bouchart A4 - Sandra Nehlsen-Cannarella A5 - Leonard L. Bailey ED1 - Shuji Miyagawa Y1 - 2020-03-11 PY - 2020 T1 - Challenge of Xenotransplantation in Pediatric Heart Transplantation N2 - Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for over 1.3 years in monkeys. Concerning islets, islets from gene-editing pigs could work for more than one year in monkeys. It is noteworthy that one group reported a survival of adult wild-type pig islets of over 600 days. On the other hand, the progress in these preclinical trials strongly affected not only the xenotransplantation study itself but regeneration studies to use pigs as a scaffold to foster human induced pluripotent stem cells. BT - Xenotransplantation SP - Ch. 4 UR - https://doi.org/10.5772/intechopen.90321 DO - 10.5772/intechopen.90321 SN - 978-1-78985-664-4 PB - IntechOpen CY - Rijeka Y2 - 2021-05-13 ER -