TY - CHAP A1 - Siti Nurul Hidayah A2 - Manasi Gaikwad A3 - Laura Heikaus A4 - Hartmut Schl├╝ter ED1 - Xianquan Zhan Y1 - 2020-07-15 PY - 2020 T1 - Preparing Proteoforms of Therapeutic Proteins for Top-Down Mass Spectrometry N2 - A proteoform is the basic unit in a proteome, defined as its amino acid sequence + post-translational modifications + spatial conformation + localization + cofactors + binding partners + a function, which is the final functional performer of a gene. Studies on proteoforms offer in-depth insights and can lead to the discovery of reliable biomarkers and therapeutic targets for effective prediction, diagnosis, prognostic assessment, and therapy of disease. This book focuses on the concept, study, and applications of proteoforms. Chapters cover such topics as methodologies for identifying and preparing proteoforms, proteoform pattern alteration in pituitary adenomas, and proteoforms in leukemia. BT - Proteoforms SP - Ch. 3 UR - https://doi.org/10.5772/intechopen.89644 DO - 10.5772/intechopen.89644 SN - 978-1-83880-034-5 PB - IntechOpen CY - Rijeka Y2 - 2021-10-23 ER -