TY - CHAP A1 - Jiang Xu A2 - Kaori Noridomi A3 - Lin Chen ED1 - Isam Jaber Al-Zwaini ED2 - Ali AL-Mayahi Y1 - 2019-06-12 PY - 2019 T1 - Structure-Based Approaches to Antigen-Specific Therapy of Myasthenia Gravis N2 - Myasthenia gravis is a rare potentially fatal chronic autoimmune disorder. Circulating autoantibodies directed against components of the neuromuscular junction of skeletal muscles, most commonly nicotinic acetylcholine receptor and associated protein in the postsynaptic membrane, block neuromuscular transmission resulting in muscle weakness. This muscle weakness typically worsens with continued activity, improves on rest, and is of variable severity ranging from mild ocular muscle weakness to severe generalized muscle weakness, involving the respiratory muscle with impending respiratory failure. The worldwide prevalence of myasthenia gravis is 100-200 per million population, affecting more than 700,000 people all over the world. The prevalence rate has increased since the 1950s due to improved diagnostic precision and decreased mortality rate. BT - Selected Topics in Myasthenia Gravis SP - Ch. 4 UR - https://doi.org/10.5772/intechopen.84715 DO - 10.5772/intechopen.84715 SN - 978-1-83880-830-3 PB - IntechOpen CY - Rijeka Y2 - 2020-09-19 ER -