TY - CHAP A1 - Tianbo Li A2 - Jun Chen ED1 - Kaneez Fatima Shad Y1 - 2018-10-10 PY - 2018 T1 - Voltage-Gated Sodium Channels in Drug Discovery N2 - Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins. BT - Ion Channels in Health and Sickness SP - Ch. 2 UR - https://doi.org/10.5772/intechopen.78256 DO - 10.5772/intechopen.78256 SN - 978-1-78984-228-9 PB - IntechOpen CY - Rijeka Y2 - 2021-05-11 ER -