TY - CHAP A1 - Otto L.D. Cerqueira A2 - Gissele Rolemberg Oliveira Silva A3 - Igor de Luna Vieira A4 - Marlous Vinícius Gomes Lana A5 - Nadine Gimenez A6 - Otavio Augusto Rodrigues A7 - Paulo Roberto Del Valle A8 - Samir Andrade Mendonça A9 - Bryan E. Strauss ED1 - Houria Bachtarzi Y1 - 2019-03-13 PY - 2019 T1 - Gene-based Interventions for Cancer Immunotherapy N2 - Ongoing advances in pharmaceutical biotechnology have paved the way to ground-breaking new biological therapeutic modalities, offering the possibility of a durable curative approach for a number of life-threatening diseases, for which the medical need is as yet unmet. Over the past decades, gene therapy has seen a massive transformation from a proof-of-concept approach to a clinical reality culminating in the regulatory approval of state-of-the-art products in the European Union and in the United States. This book captures some of the scientific progresses notably in gene transfer technologies and translational development of in vivo and ex vivo gene therapy interventions in the treatment of a broad range of complex and debilitating non-inherited and inherited disorders such as: human immunodeficiency virus 1 (HIV-1) infection, cancer, cystic fibrosis, hereditary retinopathies, haemophilia B, cardiac diseases, and chronic liver fibrosis. BT - In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders SP - Ch. 5 UR - https://doi.org/10.5772/intechopen.80386 DO - 10.5772/intechopen.80386 SN - 978-1-78985-718-4 PB - IntechOpen CY - Rijeka Y2 - 2021-01-22 ER -