TY - CHAP A1 - Akikazu Takada A2 - Fumiko Shimizu A3 - Junichi Masuda ED1 - Cristina Manuela Drăgoi ED2 - Alina Crenguţa Nicolae Y1 - 2018-11-21 PY - 2018 T1 - Measurement of Plasma Tryptophan Metabolites: Clinical and Experimental Application for Depression and Stress States Assessment N2 - Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the integrative molecular mechanisms of the organism, based on interconnections of the regulatory systems: neural, endocrine, immune, and genetic, conveying into the uniqueness of human architecture. This book provides a systematic and updated overview of melatonin biochemical mechanisms of action, pharmacological features, and clinical uses, clutching the subject with complete details of pharmaceutical formulations designed for different routes of administration and different health issues, aiming at optimal melatonin bioavailability when therapeutically delivered. The book addresses a broad range of audiences, from healthcare professionals, medically and pharmaceutically based, to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge of the physiological and pathological implications of melatonin and its metabolites. BT - Melatonin SP - Ch. 7 UR - https://doi.org/10.5772/intechopen.78560 DO - 10.5772/intechopen.78560 SN - 978-1-78984-505-1 PB - IntechOpen CY - Rijeka Y2 - 2019-11-18 ER -