TY - CHAP A1 - Pedro CecĂ­lio A2 - Fabiano Oliveira A3 - Anabela Cordeiro da Silva ED1 - Farhat Afrin ED2 - Hassan Hemeg Y1 - 2018-10-10 PY - 2018 T1 - Vaccines for Human Leishmaniasis: Where Do We Stand and What Is Still Missing? N2 - Leishmania parasites plague the mammalian host causing high morbidity and mortality. The parasites persist in the hostile milieu, crippling its defensive arsenal. In the face of mounting resistance to an antiquated drug arsenal, new approaches are urgently desired to keep the infection at bay. Furthermore, to strengthen the leishmaniasis elimination drive, particular emphasis has to be laid on identification of new targets and vaccination strategies. This book gives a brief glimpse of the epidemiology of leishmaniasis, immune evasion, vaccination, and therapeutic modalities that may work by untangling the immunological cross-wires of pathogenic cross-talk. The Conventional treatment and its drawbacks, the prospects of phytotherapy and nanomedicines, are also discussed. The identification of drug targets with the aim of designing inhibitors is also exemplified. BT - Leishmaniases as Re-emerging Diseases SP - Ch. 5 UR - https://doi.org/10.5772/intechopen.75000 DO - 10.5772/intechopen.75000 SN - 978-1-78984-102-2 PB - IntechOpen CY - Rijeka Y2 - 2020-01-27 ER -