TY - CHAP A1 - Juliana Ide Aoki A2 - Sandra Marcia Muxel A3 - Juliane Cristina Ribeiro Fernandes A4 - Lucile Maria Floeter-Winter ED1 - Farhat Afrin ED2 - Hassan Hemeg Y1 - 2018-10-10 PY - 2018 T1 - The Polyamine Pathway as a Potential Target for Leishmaniases Chemotherapy N2 - Leishmania parasites plague the mammalian host causing high morbidity and mortality. The parasites persist in the hostile milieu, crippling its defensive arsenal. In the face of mounting resistance to an antiquated drug arsenal, new approaches are urgently desired to keep the infection at bay. Furthermore, to strengthen the leishmaniasis elimination drive, particular emphasis has to be laid on identification of new targets and vaccination strategies. This book gives a brief glimpse of the epidemiology of leishmaniasis, immune evasion, vaccination, and therapeutic modalities that may work by untangling the immunological cross-wires of pathogenic cross-talk. The Conventional treatment and its drawbacks, the prospects of phytotherapy and nanomedicines, are also discussed. The identification of drug targets with the aim of designing inhibitors is also exemplified. BT - Leishmaniases as Re-emerging Diseases SP - Ch. 7 UR - https://doi.org/10.5772/intechopen.75867 DO - 10.5772/intechopen.75867 SN - 978-1-78984-102-2 PB - IntechOpen CY - Rijeka Y2 - 2021-03-01 ER -