TY - CHAP A1 - Yong Chul Lee A2 - So Ri Kim ED1 - Kuan-Hsiang Gary Huang ED2 - Chen Hsuan Sherry Tsai Y1 - 2018-07-04 PY - 2018 T1 - Subcellular Organelles in Immune Responses of Severe Asthma: The Roles of Mitochondria and Endoplasmic Reticulum N2 - Asthma is a severe and growing threat affecting both children and adults in both developing and developed world, currently affecting approximately 8% of US population. It is becoming increasingly recognized as a syndrome constituted by airway obstruction, airway hyperresponsiveness, and airway inflammation with different causes, associated risk factors, and underlying pathophysiology. The advances in basic and clinical research of asthma have accelerated over the past 20 years with increasing diagnostic tools, especially biomarkers, that led to specific characterization of individual patient's asthma pathophysiology, or disease "phenotype" and "endotype," which allowed precision medicine therapies, including new asthma biologics. This book aims to update the paradigm shifts in precision medicine of asthma diagnosis and management, driven by underlying phenotypes or endotypes. BT - Asthma Diagnosis and Management SP - Ch. 7 UR - https://doi.org/10.5772/intechopen.75148 DO - 10.5772/intechopen.75148 SN - 978-1-78923-323-0 PB - IntechOpen CY - Rijeka Y2 - 2021-12-08 ER -