TY - CHAP A1 - Julia Carracedo A2 - Rafael Ramírez-Carracedo A3 - Matilde Alique and Rafael Ramírez-Chamond ED1 - Helena Lenasi Y1 - 2018-10-24 PY - 2018 T1 - Endothelial Cell Senescence in the Pathogenesis of Endothelial Dysfunction N2 - The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations. BT - Endothelial Dysfunction SP - Ch. 3 UR - https://doi.org/10.5772/intechopen.73024 DO - 10.5772/intechopen.73024 SN - 978-1-78984-254-8 PB - IntechOpen CY - Rijeka Y2 - 2021-10-26 ER -