TY - CHAP A1 - Aye San A2 - Magid Fahim A3 - Katrina Campbell A4 - Carmel M. Hawley and David W. Johnson ED1 - Pinar Atukeren Y1 - 2018-05-09 PY - 2018 T1 - The Role of Oxidative Stress and Systemic Inflammation in Kidney Disease and Its Associated Cardiovascular Risk N2 - Oxidative stress plays a crucial role in the pathophysiology of various diseases when there is a disruption of the intracellular redox balance and the homeostatic balance between cellular oxidants and antioxidants. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) react with molecular targets including proteins, lipids, and nucleic acids contributing to mitochondrial injury and cellular dysfunction. This book intends to provide the readers with an extensive overview of the novel approaches and prospects based on oxidative and nitrosative stress in the pathophysiology of various diseases and in the current treatment strategies with antioxidants. BT - Novel Prospects in Oxidative and Nitrosative Stress SP - Ch. 2 UR - https://doi.org/10.5772/intechopen.73239 DO - 10.5772/intechopen.73239 SN - 978-1-78923-087-1 PB - IntechOpen CY - Rijeka Y2 - 2022-01-23 ER -