TY - CHAP A1 - Michael Lattke A2 - Thomas Wirth ED1 - Maria Teresa Gentile ED2 - Luca Colucci D’Amato Y1 - 2018-03-21 PY - 2018 T1 - Signaling Pathways Regulating the Pathophysiological Responses of Astrocytes: A Focus on the IKK/NF-κB System N2 - A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases. BT - Astrocyte SP - Ch. 2 UR - https://doi.org/10.5772/intechopen.72283 DO - 10.5772/intechopen.72283 SN - 978-953-51-3886-0 PB - IntechOpen CY - Rijeka Y2 - 2019-11-17 ER -