TY - CHAP A1 - Lin Hai Kurahara A2 - Keizo Hiraishi A3 - Kunihiko Aoyagi A4 - Yaopeng Hu A5 - Miho Sumiyoshi A6 - Ryuji Inoue ED1 - Samuel Huber Y1 - 2016-10-26 PY - 2016 T1 - Intestinal Fibroblast/Myofibroblast TRP Channels in Inflammatory Bowel Disease N2 - The incidence of chronic inflammatory and autoimmune diseases is steadily increasing. Inflammatory bowel disease (IBD) is one example of a chronic inflammatory disease, which primarily affects the intestine but may also affect extraintestinal organs. The exact pathogenesis of IBD is currently unknown. However, it is clear that the pathogenesis is complex, involving barrier defects, changes in the intestinal microbiome, and chronic immune activation. This book aims to summarize basic aspects of these complex interactions between barrier function, microbiome, and the immune system. Of note, there is currently no cure for IBD. However, several therapies have evolved in the last years, which are overall able to-at least temporarily-suppress IBD. These therapies and the underlying mechanism are discussed. BT - New Insights into Inflammatory Bowel Disease SP - Ch. 8 UR - https://doi.org/10.5772/64830 DO - 10.5772/64830 SN - 978-953-51-2755-0 PB - IntechOpen CY - Rijeka Y2 - 2020-09-19 ER -