TY - CHAP A1 - Sollinger, Hans A2 - Handorf, Andrew A3 - Alam, Tausif ED - Kormann, Michael Y1 - 2016-05-18 PY - 2016 T1 - Insulin Gene Therapy for Type 1 Diabetes Mellitus: Unique Challenges Require Innovative Solutions N2 - Site-specific endonucleases create double-strand breaks within the genome and can be targeted to literally any genetic mutation. Together with a repair template, a correction of the defective locus becomes possible. This book offers insight into the modern tools of genome editing, their hurdles and their huge potential. A new era of in vivo genetic engineering has begun. BT - Modern Tools for Genetic Engineering SP - Ch. 6 UR - https://doi.org/10.5772/62657 DO - 10.5772/62657 SN - 978-953-51-2234-0 PB - InTech CY - Rijeka Y2 - 2018-06-21 ER -