TY - CHAP A1 - Andrew M Handorf A2 - Hans W Sollinger A3 - Tausif Alam ED1 - Michael S.D. Kormann Y1 - 2016-05-18 PY - 2016 T1 - Insulin Gene Therapy for Type 1 Diabetes Mellitus: Unique Challenges Require Innovative Solutions N2 - Site-specific endonucleases create double-strand breaks within the genome and can be targeted to literally any genetic mutation. Together with a repair template, a correction of the defective locus becomes possible. This book offers insight into the modern tools of genome editing, their hurdles and their huge potential. A new era of in vivo genetic engineering has begun. BT - Modern Tools for Genetic Engineering SP - Ch. 6 UR - https://doi.org/10.5772/62657 DO - 10.5772/62657 SN - 978-953-51-2234-0 PB - IntechOpen CY - Rijeka Y2 - 2019-01-23 ER -