TY - CHAP A1 - Sergio López-Manzaneda A2 - Sara Fañanas-Baquero A3 - Virginia Nieto- Romero A4 - Francisco-Jose Roman-Rodríguez A5 - Maria Fernandez-Garcia A6 - Maria J. Pino-Barrio A7 - Fatima Rodriguez-Fornes A8 - Begoña Diez- Cabezas A9 - Maria Garcia-Bravo A10 - Susana Navarro A11 - Oscar Quintana- Bustamante A12 - Jose C. Segovia ED1 - Michael S.D. Kormann Y1 - 2016-05-18 PY - 2016 T1 - Gene Editing in Adult Hematopoietic Stem Cells N2 - Site-specific endonucleases create double-strand breaks within the genome and can be targeted to literally any genetic mutation. Together with a repair template, a correction of the defective locus becomes possible. This book offers insight into the modern tools of genome editing, their hurdles and their huge potential. A new era of in vivo genetic engineering has begun. BT - Modern Tools for Genetic Engineering SP - Ch. 5 UR - https://doi.org/10.5772/62383 DO - 10.5772/62383 SN - 978-953-51-2234-0 PB - IntechOpen CY - Rijeka Y2 - 2021-06-22 ER -