TY - CHAP A1 - De Breucker Sandra A2 - Pepersack Thierry A3 - Bier Jean-Christophe ED1 - Inga Zerr Y1 - 2015-07-01 PY - 2015 T1 - The Alzheimer’s Patient in the Emergency Department — Specificities of Care N2 - There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease. BT - Alzheimer's Disease SP - Ch. 12 UR - https://doi.org/10.5772/59326 DO - 10.5772/59326 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-07-25 ER -