TY - CHAP A1 - Eduardo Fuentes A2 - Luis Guzmán A3 - Marcelo Alarcón A4 - Rodrigo Moore and Iván Palomo ED1 - Krasimir Kolev Y1 - 2014-05-07 PY - 2014 T1 - Thrombolytic/Fibrinolytic Mechanism of Natural Products N2 - This book familiarizes the reader with some recent trends in the theory and practice of thrombolysis. It covers the field of fibrinolysis from the standpoint of basic scientists and clinicians and delivers the state-of-the-art information on the biochemistry and pharmacology of fibrinolysis, as well as related novel methodological and diagnostic tools in the field. An introductory chapter summarizes the basic molecular mechanisms in fibrinolysis (plasminogen, its endogenous activators and their inhibitors, plasmin and its inhibitors). Recent developments in our understanding of fibrin formation are described in the context of its impact on fibrinolysis. The discussion of neutrophil extracellular traps in the modulation of fibrin assembly and the consequences regarding plasminogen activation and plasmin action addresses a novel aspect of fibrinolysis. BT - Fibrinolysis and Thrombolysis SP - Ch. 5 UR - https://doi.org/10.5772/57608 DO - 10.5772/57608 SN - PB - IntechOpen CY - Rijeka Y2 - 2019-11-18 ER -