TY - CHAP A1 - S. L. M. van Loon A2 - A. I. P. M. Smits A3 - A. Driessen-Mol A4 - F. P. T. Baaijens and C. V. C. Bouten ED1 - Elena Aikawa Y1 - 2013-06-12 PY - 2013 T1 - The Immune Response in In Situ Tissue Engineering of Aortic Heart Valves N2 - Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future. BT - Calcific Aortic Valve Disease SP - Ch. 8 UR - https://doi.org/10.5772/54354 DO - 10.5772/54354 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-03-29 ER -