TY - CHAP A1 - Steven W. Kerrigan ED1 - Steven W. Kerrigan Y1 - 2013-06-27 PY - 2013 T1 - Platelet Bacterial Interactions in the Pathogenesis of Infective Endocarditis — Part II: The Staphylococcus N2 - Endocarditis is an inflammation of the lining of the heart and valves. It can be due to a non-infectious cause but when the inflammation is associated with an infection, usually bacterial, it is known as infective endocarditis. It is typically characterized by the development of a large septic thrombus on one of the cardiac valves. As this thrombus grows, it can lead to valve failure or may fragment forming a septic embolus that is associated with high mortality if the target of the embolus is the brain, heart or lung. This book reviews multi-organ complications associated with Infective endocarditis including significant recent advances in molecular mechanisms underlying thrombus formation on the cardiac valve, anti-microbial treatment and surgery. BT - Recent Advances in Infective Endocarditis SP - Ch. 3 UR - https://doi.org/10.5772/55911 DO - 10.5772/55911 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-09-27 ER -