TY - CHAP A1 - Ioan Tilea A2 - Horatiu Suciu A3 - Brindusa Tilea A4 - Cristina Maria Tatar A5 - Mihaela Ispas A6 - Razvan Constantin Serban ED1 - Elena Aikawa Y1 - 2013-06-12 PY - 2013 T1 - Anatomy and Function of Normal Aortic Valvular Complex N2 - Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future. BT - Calcific Aortic Valve Disease SP - Ch. 2 UR - https://doi.org/10.5772/53403 DO - 10.5772/53403 SN - PB - IntechOpen CY - Rijeka Y2 - 2022-01-24 ER -