TY - CHAP A1 - Erik Fung A2 - Masanori Aikawa ED1 - Elena Aikawa Y1 - 2013-06-12 PY - 2013 T1 - Notch Signaling in Congenital and Acquired Aortic Valve Disease N2 - Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future. BT - Calcific Aortic Valve Disease SP - Ch. 4 UR - https://doi.org/10.5772/56533 DO - 10.5772/56533 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-08-05 ER -