TY - CHAP A1 - Jie Yang A2 - Jie Chen ED1 - Uday Kishore Y1 - 2013-05-15 PY - 2013 T1 - QSAR Analysis of Purine-Type and Propafenone-Type Substrates of P-Glycoprotein Targeting β-Amyloid Clearance N2 - This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking. BT - Neurodegenerative Diseases SP - Ch. 11 UR - https://doi.org/10.5772/54975 DO - 10.5772/54975 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-08-06 ER -