TY - CHAP A1 - Justin Read A2 - Cenk Suphioglu ED1 - Uday Kishore Y1 - 2013-05-15 PY - 2013 T1 - Dropping the BACE: Beta Secretase (BACE1) as an Alzheimer’s Disease Intervention Target N2 - This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking. BT - Neurodegenerative Diseases SP - Ch. 10 UR - https://doi.org/10.5772/53603 DO - 10.5772/53603 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-08-09 ER -