TY - CHAP A1 - Sergio P. Bydlowski A2 - Debora Levy A3 - Jorge M.L. Ruiz A4 - Juliana Pereira ED1 - Kamran Alimoghaddam Y1 - 2013-05-08 PY - 2013 T1 - Hematopoietic Stem Cell Niche: Role in Normal and Malignant Hematopoiesis N2 - Stem cells have a prominent role in normal life and also in pathogenesis of disorders. Today, these cells are clinically applicable in hematopoietic stem cell transplantation but expansion of their application in many more disorders needs more work. For safe and effective application of these cells, we need better knowledge of their biology, their interaction with other cells (especially supporting niche cells), growth, maturation and also immigration of stem cells through body in normal and abnormal conditions. Also for clinical application we need to understand better, their separation methods and safe manipulation. This book is written to clarify some aspects of stem cell biology, their characteristics, assessment of damage to cells during ex vivo manipulation and also their role in a model of cancers (chronic myeloid leukemia). BT - Stem Cell Biology in Normal Life and Diseases SP - Ch. 2 UR - https://doi.org/10.5772/55508 DO - 10.5772/55508 SN - PB - IntechOpen CY - Rijeka Y2 - 2019-11-12 ER -