TY - CHAP A1 - Bela Balint A2 - Slobodan Obradovic A3 - Milena Todorovic A4 - Mirjana Pavlovic and Biljana Mihaljevic ED1 - Kamran Alimoghaddam Y1 - 2013-05-08 PY - 2013 T1 - Stem Cell-Based (Auto)Grafting: From Innovative Research Toward Clinical Use in Regenerative Medicine N2 - Stem cells have a prominent role in normal life and also in pathogenesis of disorders. Today, these cells are clinically applicable in hematopoietic stem cell transplantation but expansion of their application in many more disorders needs more work. For safe and effective application of these cells, we need better knowledge of their biology, their interaction with other cells (especially supporting niche cells), growth, maturation and also immigration of stem cells through body in normal and abnormal conditions. Also for clinical application we need to understand better, their separation methods and safe manipulation. This book is written to clarify some aspects of stem cell biology, their characteristics, assessment of damage to cells during ex vivo manipulation and also their role in a model of cancers (chronic myeloid leukemia). BT - Stem Cell Biology in Normal Life and Diseases SP - Ch. 7 UR - https://doi.org/10.5772/54473 DO - 10.5772/54473 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-07-25 ER -