TY - CHAP A1 - Zhanqiu Yang A2 - Hai-Rong Xiong ED1 - Luca Ceccherini-Nelli ED2 - Barbara Matteoli Y1 - 2012-10-17 PY - 2012 T1 - In vitro, Tissue-Based Models as a Replacement for Animal Models in Testing of Drugs at the Preclinical Stages N2 - This book describes many aspects of tissue culture models in an extensive manner. The book includes many topics like, the development of cultural methods to produce massive neuronal syncytial connections and induce their fusion with formation of bi- and multinucleated cells, the applicability in research of cell lines derived from the cultivation of placenta derived cells and cell populations with properties of progenitor/stem cells, the procedures that may be used to regenerate cartilage tissue with appropriate mechanical properties, the improvements made in the use of cell culture for virus isolation, tissue-based models for HCV replication in vitro, cultures to study the pathogenicity of enteropathogenic bacteria, the use of viral DNA and cDNA Array in the diagnosis of respiratory tract infections (RTI) in comparison with routine diagnosis methods. BT - Biomedical Tissue Culture SP - Ch. 5 UR - https://doi.org/10.5772/52300 DO - 10.5772/52300 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-11-27 ER -