TY - CHAP A1 - Ota Fuchs ED1 - Margarita Guenova ED2 - Gueorgui Balatzenko Y1 - 2013-05-15 PY - 2013 T1 - Treatment of Myelodysplastic Syndrome and Acute Myeloid Leukemia by Immunomodulatory and Epigenetic Drugs N2 - Leukemias are a group of heterogeneous neoplastic disorders, that differ significantly in terms of morhological, immunophenotypic, cytogenetic and molecular features of malignant cells. These specific features reflect the differences in the spectrum of underlying biological alterations involved in malignant transformation, and/or variations in the level of hematopoietic stem cells hierarchy where the transforming events occur. The continuous and rather extensive influx of new information regarding the pathogenesis and treatment of leukemias requires a frequent updating of this topic. The primary objective of this book is to provide the specialists involved in the diagnosis and management of acute and chronic leukemias with a comprehensive and concise information on some important theoretical and practical issues of the biology and clinical presentation, the diagnosis, treatment and follow up of patients with leukemias. BT - Leukemia SP - Ch. 5 UR - https://doi.org/10.5772/52099 DO - 10.5772/52099 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-09-25 ER -