TY - CHAP A1 - Vaclav Liska A2 - Vladislav Treska A3 - Hynek Mirka A4 - Ondrej Vycital A5 - Jan Bruha A6 - Pavel Pitule A7 - Jana Kopalova A8 - Tomas Skalicky A9 - Alan Sutnar A10 - Jan Benes A11 - Jiri Kobr A12 - Alena Chlumska A13 - Jaroslav Racek A14 - Ladislav Trefil ED1 - Pedro M. Baptista Y1 - 2012-05-16 PY - 2012 T1 - Liver Parenchyma Regeneration in Connection with Extended Surgical Procedure - Experiment on Large Animal N2 - Doctors and scientists have been aware of the "phenomenom" of liver regeneration since the time of the ancient Greeks, illustrated by the mythic tale of Prometheus' punishment. Nevertheless, true insight into its intricate mechanisms have only become available in the 20th century. Since then, the pathways and mechanisms involved in restoring the liver to its normal function after injury have been resolutely described and characterized, from the hepatic stem/progenitor cell activation and expansion to the more systemic mechanisms involving other tissues and organs like bone-marrow progenitor cell mobilization. This book describes some of the complex mechanisms involved in liver regeneration and provides examples of the most up-to-date strategies used to induce liver regeneration, both in the clinic and in the laboratory. The information presented will hopefully benefit not only professionals in the liver field, but also people in other areas of science (pharmacology, toxicology, etc) that wish to expand their knowledge of the fundamental biology that orchestrates liver injury and regeneration. BT - Liver Regeneration SP - Ch. 9 UR - https://doi.org/10.5772/38130 DO - 10.5772/38130 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-08-07 ER -