TY - CHAP A1 - Keishiro Aoyagi A2 - Kikuo Kouhuji A3 - Kazuo Shirouzu ED1 - Raimundas Lunevicius Y1 - 2012-04-27 PY - 2012 T1 - The Significance of the Ki-67 Labeling Index, the Expression of c-kit, p53, and bcl-2, and the Apoptotic Count on the Prognosis of Gastrointestinal Stromal Tumor N2 - Almost 30 years have gone by since the postulation that GISTs derive from mesenchymal stem elements, and only 15 years have gone by since the definitive detection of origin of GISTs. Research in the last decade was more focused upon the justification of imatinib mezylate therapy in GISTs and clarification why a secondary resistance that occurred during the kinase inhibitors therapy. The era of therapy for GISTs, targeting the primary activating mutations in the KIT proto-oncogene; is being proclaimed as bringing the message of special importance to the pathologist role in multidisciplinary team that are responsible for treating patients with locally advanced or metastatic GIST. This is the first conclusive message forthcoming from this book. On the other hand, the book provides summarised and case-based knowledge on current management of gastrointestinal and extragastrointestinal stromal tumours. We hope that this book may be considered as a worthwhile timely addition to clinical science dissemination, medical education, further basic and clinical research. BT - Gastrointestinal Stromal Tumor SP - Ch. 7 UR - https://doi.org/10.5772/32356 DO - 10.5772/32356 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-09-26 ER -