TY - CHAP A1 - Brice E. T. Nouthe A2 - Maya Saleh A3 - Shao-Ling Zhang A4 - John S. D. Chan ED1 - John S. D. Chan Y1 - 2012-04-20 PY - 2012 T1 - Renal Angiotensinogen Gene Expression and Tubular Atrophy in Diabetic Nephropathy N2 - Internationally renowned experts have provided data on their own studies, and discuss the relative usefulness of their work in relation to diabetic nephropathy. The first section describes the novel role of intrarenal renin-angiotensin-aldosterone system (RAAS) and oxidative stress in the development of diabetic nephropathy and discusses the current and novel pharmacological interventions in the treatment of diabetic nephropathy. The second section discusses other important contributors outside of the RAAS in the pathogenesis of diabetic nephropathy including AGE/RAGE, epithelial-mesenchymal-transition (EMT) and immune cytokines. Features: Provides novel information on various pathophysiological determinants in the development of diabetic nephropathy Provides novel information on various pharmacological interventions of diabetic nephropathy BT - Diabetic Nephropathy SP - Ch. 2 UR - https://doi.org/10.5772/34864 DO - 10.5772/34864 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-09-18 ER -