TY - CHAP A1 - Dulce Elena Casarini A2 - Danielle Yuri Arita A3 - Tatiana Sousa Cunha A4 - Fernanda Aparecida Ronchi A5 - Danielle Sanches Arag√£o A6 - Rodolfo Mattar Rosa A7 - Nadia Sousa Cunha Bertoncello A8 - Fernanda Klein Marcondes ED1 - John S. D. Chan Y1 - 2012-04-20 PY - 2012 T1 - Up-Regulation of Renin-Angiotensin System in Diabetes and Hypertension: Implications on the Development of Diabetic Nephropathy N2 - Internationally renowned experts have provided data on their own studies, and discuss the relative usefulness of their work in relation to diabetic nephropathy. The first section describes the novel role of intrarenal renin-angiotensin-aldosterone system (RAAS) and oxidative stress in the development of diabetic nephropathy and discusses the current and novel pharmacological interventions in the treatment of diabetic nephropathy. The second section discusses other important contributors outside of the RAAS in the pathogenesis of diabetic nephropathy including AGE/RAGE, epithelial-mesenchymal-transition (EMT) and immune cytokines. Features: Provides novel information on various pathophysiological determinants in the development of diabetic nephropathy Provides novel information on various pharmacological interventions of diabetic nephropathy BT - Diabetic Nephropathy SP - Ch. 1 UR - https://doi.org/10.5772/36852 DO - 10.5772/36852 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-08-05 ER -