TY - CHAP A1 - Ron Zohar ED1 - Haim Tal Y1 - 2012-04-04 PY - 2012 T1 - Signals Between Cells and Matrix Mediate Bone Regeneration N2 - Bone is a specialized connective tissue, most prominently characterized by its mineralized organic matrix that imparts the physical properties that allow bone tissue to resist load, to support functional organs, and to protect highly sensitive body parts. Bone loss and bone damage may occur as a result of genetic conditions, infectious diseases, tumours, and trauma. Bone healing and repair, involves integrative activity of native tissues and living cells, and lends itself to the incorporation of naturally derived or biocompatible synthetic scaffolds, aimed at replacing missing or damaged osseous tissues. There are several modalities of bone regeneration including tissue engineering, guided bone regeneration, distraction ontogenesis, and bone grafting. This book concentrates on such procedures that may well be counted among the recent outstanding breakthroughs in bone regenerative therapy. BT - Bone Regeneration SP - Ch. 3 UR - https://doi.org/10.5772/38292 DO - 10.5772/38292 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-10-01 ER -