TY - CHAP A1 - Raffaella Bonecchi1 A2 - Benedetta Savino1 A3 - Matthieu Pesant1 A4 - Massimo Locati1 ED1 - Subhra K. Biswas Y1 - 2012-03-30 PY - 2012 T1 - Cell Lineage Commitment and Tumor Microenvironment as Determinants for Tumor-Associated Myelomonocytic Cells Plasticity N2 - Tumor microenvironment represents an extremely dynamic niche shaped by the interplay of different cell types (e.g. tumor cells, stromal cells), their soluble products (e.g.cytokines, chemokines and growth factors) and varied physico-chemical conditions (e.g low oxygen concentration or hypoxia). Recent studies have identified myelomonocytic cells as key players in regulating the tumor microenvironment and hence, tumor progression in a variety of cancers. In view of these findings, the present book attemps to provide a comprehensive account of the diversity of tumor microenvironment across different cancers and how myelomonocytic cells have taken the center-stage in regulating this niche to direct cancer progression. A better understanding of the myelomonocytic cells and the mechanisms by which they regulate cancer progression will open new vistas in cancer therapeutics. BT - Tumor Microenvironment and Myelomonocytic Cells SP - Ch. 1 UR - https://doi.org/10.5772/34377 DO - 10.5772/34377 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-08-07 ER -