TY - CHAP A1 - Takatoshi Fujiki ED1 - Weibo Cai ED2 - Hao Hong Y1 - 2012-03-30 PY - 2012 T1 - Prediction of Combinatorial Protein-Protein Interaction from Expression Data Based on Conditional Probability N2 - Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others. BT - Protein-Protein Interactions SP - Ch. 6 UR - https://doi.org/10.5772/38467 DO - 10.5772/38467 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-06-22 ER -