TY - CHAP A1 - Jiaming Qian A2 - Hong Yang A3 - Jingnan Li A4 - Jian Wang ED1 - Sanjay K. Srivastava Y1 - 2012-03-23 PY - 2012 T1 - Characterization of the Molecular Genetic Mechanisms that Contribute to Pancreatic Cancer Carcinogenesis N2 - This book provides the reader with an overall understanding of the biology of pancreatic cancer, hereditary, complex signaling pathways and alternative therapies. The book explains nutrigenomics and epigenetics mechanisms such as DNA methylation, which may explain the etiology or progression of pancreatic cancer. Book also summarizes the molecular control of oncogenic pathways such as K-Ras and KLF4. Since pancreatic cancer metastasizes to vital organs resulting in poor prognosis, special emphasis is given to the mechanism of tumor cell invasion and metastasis. Role of nitric oxide and Syk kinase in tumor metastasis is discussed in detail. Prevention strategies for pancreatic cancer are also described. The molecular mechanisms of the anti-cancer effects of curcumin, benzyl isothiocyante and vitamin D are discussed in detail. Furthermore, this book covers the basic mechanisms of resistance of pancreatic cancer to chemotherapy drugs such as gemcitabine and 5-flourouracil. BT - Pancreatic Cancer SP - Ch. 3 UR - https://doi.org/10.5772/28982 DO - 10.5772/28982 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-09-20 ER -