TY - CHAP A1 - Kazuo Yamagata ED1 - Maurizio Balestrino Y1 - 2012-03-16 PY - 2012 T1 - Ischemic Neurodegeneration in Stroke-Prone Spontaneously Hypertensive Rats and Its Prevention with Antioxidants Such as Polyphenols N2 - This book reports innovations in the preclinical study of stroke, including - novel tools and findings in animal models of stroke, - novel biochemical mechanisms through which ischemic damage may be both generated and limited, - novel pathways to neuroprotection. Although hypothermia has been so far the sole "neuroprotection" treatment that has survived the translation from preclinical to clinical studies, progress in both preclinical studies and in the design of clinical trials will hopefully provide more and better treatments for ischemic stroke. This book aims at providing the preclinical scientist with innovative knowledge and tools to investigate novel mechanisms of, and treatments for, ischemic brain damage. BT - Advances in the Preclinical Study of Ischemic Stroke SP - Ch. 1 UR - https://doi.org/10.5772/31507 DO - 10.5772/31507 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-05-10 ER -