TY - CHAP A1 - Zandrea Ambrose ED1 - Patrick Arbuthnot Y1 - 2012-03-14 PY - 2012 T1 - Use of Animal Models for Anti-HIV Drug Development N2 - The articles that appear in Antiviral Drugs - Aspects of Clinical Use and Recent Advances cover several topics that reflect the varied mechanisms of viral disease pathogenesis and treatment. Clinical management and new developments in the treatment of virus-related diseases are the two main sections of the book. The first part reviews the treatment of hepatitis C virus infection, the management of virus-related acute retinal necrosis, the use of leflunomide therapy in renal transplant patients, and mathematical modeling of HIV-1 treatment responses. Basic research topics are dealt with in the second half of the book. New developments in the treatment of the influenza virus, the use of animal models for HIV-1 drug development, the use of single chain camelid antibodies against negative strand RNA viruses, countering norovirus infection, and the use of plant extracts to treat herpes simplex virus infection are described. The content of the book is not intended to be comprehensive, but aims to provide the reader with insights into selected aspects of established and new viral therapies. BT - Antiviral Drugs SP - Ch. 5 UR - https://doi.org/10.5772/33484 DO - 10.5772/33484 SN - PB - IntechOpen CY - Rijeka Y2 - 2019-11-14 ER -