TY - CHAP A1 - Hirokazu Yokoyama A2 - Haruko-Shiraishi Yokoyama A3 - Toshifumi Hibi ED1 - Ferdous Rastgar Jazii Y1 - 2012-03-07 PY - 2012 T1 - The Interaction Between the Metabolism of Retinol and Ethanol in Esophageal Mucosa – A Possible Mechanism of Esophageal Cancer in Alcoholics N2 - Esophageal Cancer illustrates recent achievements and investigations in the esophageal tumorigenesis from different perspectives. Readers find mechanisms involved in esophageal tumorigenesis, cellular, molecular, genetic, epigenetics, and proteomics, their relevance as the novel biomarkers and application in esophageal cancer diagnosis and therapy. The book covers detailed effect of nutritional factors in addition to ethanol metabolic pathway in the inhibition of retinoic acid metabolism and supply. Diagnosis, classification, and treatment of esophageal cancer, application of both surgical and non surgical methods as well as follow up of the disease are described in detail. Moreover readers are endowed with especial features of esophageal cancer such as multiple early stage malignant melanoma and pulmonary edema induced by esophagectomy, the two features that received less attention elsewhere in literature. BT - Esophageal Cancer SP - Ch. 5 UR - https://doi.org/10.5772/37383 DO - 10.5772/37383 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-10-27 ER -