TY - CHAP A1 - M. Scott Harris A2 - Oranee T. Daniels ED1 - Anthony G. Catto-Smith Y1 - 2012-03-07 PY - 2012 T1 - Core Aspects of Clinical Development and Trials in Chronic Idiopathic Constipation N2 - Constipation is common in both adults and children. Estimates would suggest a median prevalence of around 12-16% in the general population. While regarded as a minor nuisance in some cases, its consequences can be severe, with a substantial impact on quality of life. Secondary faecal soiling has a profound psychological effect at all ages. This book provides contributions from authors with a range of backgrounds which clarify the pathogenesis, diagnosis, and therapy of constipation for the general population and also for certain high risk groups. BT - Constipation SP - Ch. 11 UR - https://doi.org/10.5772/28002 DO - 10.5772/28002 SN - PB - IntechOpen CY - Rijeka Y2 - 2019-11-17 ER -