TY - CHAP A1 - Hamilton Gerhard ED1 - Gerhard Hamilton Y1 - 2012-02-29 PY - 2012 T1 - Cytokeratin 18 (CK18) and Caspase-Cleaved CK18 (ccCK18) as Response Markers in Anticancer Therapy N2 - The first chapters of the volume "Cytokeratins - Tools in Oncology" discuss multiple functions of cytokeratins in organization of the intermediary filaments in normal intestine and liver as well as microfold L cells and the usability of cytokeratins 7, 8 and 20 in tumor diagnosis in detail. Epithelial to mesenchymal transition as a mechanism important in pathogenesis is touched in another chapter, followed by several articles dealing with the role of cytokeratins for detection of disseminated tumor cells and as response markers during chemotherapy. This book is therefore destined to all cancer researchers and therapists who want to understand the diagnostic application of cytokeratins in histology and, especially, the use of anti-cytokeratin antibodies to identify viable residual tumor cells accounting for a higher risk of tumor recurrence or cancer cells responding to chemotherapy, respectively. BT - Cytokeratins SP - Ch. 8 UR - https://doi.org/10.5772/39194 DO - 10.5772/39194 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-08-09 ER -