TY - CHAP A1 - Stephen F. Previs A2 - Haihong Zhou A3 - Sheng-Ping Wang A4 - Kithsiri Herath A5 - Douglas G. Johns A6 - Thomas P. Roddy A7 - Takhar Kasumov A8 - Brian K. Hubbard ED1 - Hon-Chiu Eastwood Leung ED2 - Tsz-Kwong Man ED3 - Ricardo J. Flores Y1 - 2012-02-24 PY - 2012 T1 - Proteome Kinetics: Coupling the Administration of Stable Isotopes with Mass Spectrometry-Based Analyses N2 - Proteomics was thought to be a natural extension after the field of genomics has deposited significant amount of data. However, simply taking a straight verbatim approach to catalog all proteins in all tissues of different organisms is not viable. Researchers may need to focus on the perspectives of proteomics that are essential to the functional outcome of the cells. In Integrative Proteomics, expert researchers contribute both historical perspectives, new developments in sample preparation, gel-based and non-gel-based protein separation and identification using mass spectrometry. Substantial chapters are describing studies of the sub-proteomes such as phosphoproteome or glycoproteomes which are directly related to functional outcomes of the cells. Structural proteomics related to pharmaceutics development is also a perspective of the essence. Bioinformatics tools that can mine proteomics data and lead to pathway analyses become an integral part of proteomics. Integrative proteomics covers both look-backs and look-outs of proteomics. It is an ideal reference for students, new researchers, and experienced scientists who want to get an overview or insights into new development of the proteomics field. BT - Integrative Proteomics SP - Ch. 13 UR - https://doi.org/10.5772/29573 DO - 10.5772/29573 SN - PB - IntechOpen CY - Rijeka Y2 - 2019-01-23 ER -