TY - CHAP A1 - Jan Jurica A2 - Alexandra Sulcova ED1 - James Paxton Y1 - 2012-02-22 PY - 2012 T1 - Determination of Cytochrome P450 Metabolic Activity Using Selective Markers N2 - In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates. BT - Topics on Drug Metabolism SP - Ch. 8 UR - https://doi.org/10.5772/30236 DO - 10.5772/30236 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-05-11 ER -