TY - CHAP A1 - Robert Laprairie A2 - Greg Hosier A3 - Matthew Hogel A4 - Eileen M. Denovan-Wright ED1 - Nagehan Ersoy Tunali Y1 - 2012-02-15 PY - 2012 T1 - Alterations in Expression and Function of Phosphodiesterases in Huntington’s Disease N2 - Huntington's Disease is one of the well-studied neurodegenerative conditions, a quite devastating and currently incurable one. It is a brain disorder that causes certain types of neurons to become damaged, causing various parts of the brain to deteriorate and lose their function. This results in uncontrolled movements, loss of intellectual capabilities and behavioural disturbances. Since the identification of the causative mutation, there have been many significant developments in understanding the cellular and molecular perturbations. This book, "Huntington's Disease - Core Concepts and Current Advances", was prepared to serve as a source of up-to-date information on a wide range of issues involved in Huntington's Disease. It will help the clinicians, health care providers, researchers, graduate students and life science readers to increase their understanding of the clinical correlates, genetic aspects, neuropathological findings, cellular and molecular events and potential therapeutic interventions involved in HD. The book not only serves reviewed fundamental information on the disease but also presents original research in several disciplines, which collectively provide comprehensive description of the key issues in the area. BT - Huntington's Disease SP - Ch. 6 UR - https://doi.org/10.5772/31486 DO - 10.5772/31486 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-09-22 ER -