TY - CHAP A1 - Shin-Ichi Fukuoka A2 - Rei Kawashima A3 - Rei Asuma A4 - Katsumi Shibata A5 - Tsutomu Fukuwatari ED1 - Nagehan Ersoy Tunali Y1 - 2012-02-15 PY - 2012 T1 - Quinolinate Accumulation in the Brains of the Quinolinate Phosphoribosyltransferase (QPRT) Knockout Mice N2 - Huntington's Disease is one of the well-studied neurodegenerative conditions, a quite devastating and currently incurable one. It is a brain disorder that causes certain types of neurons to become damaged, causing various parts of the brain to deteriorate and lose their function. This results in uncontrolled movements, loss of intellectual capabilities and behavioural disturbances. Since the identification of the causative mutation, there have been many significant developments in understanding the cellular and molecular perturbations. This book, "Huntington's Disease - Core Concepts and Current Advances", was prepared to serve as a source of up-to-date information on a wide range of issues involved in Huntington's Disease. It will help the clinicians, health care providers, researchers, graduate students and life science readers to increase their understanding of the clinical correlates, genetic aspects, neuropathological findings, cellular and molecular events and potential therapeutic interventions involved in HD. The book not only serves reviewed fundamental information on the disease but also presents original research in several disciplines, which collectively provide comprehensive description of the key issues in the area. BT - Huntington's Disease SP - Ch. 5 UR - https://doi.org/10.5772/31749 DO - 10.5772/31749 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-08-06 ER -