TY - CHAP A1 - Alexandra Eder A2 - Arne Hansen A3 - Thomas Eschenhagen ED1 - William Acree Y1 - 2012-02-10 PY - 2012 T1 - Multi-Well Engineered Heart Tissue for Drug Screening and Predictive Toxicology N2 - Modern drug design and testing involves experimental in vivo and in vitro measurement of the drug candidate's ADMET (adsorption, distribution, metabolism, elimination and toxicity) properties in the early stages of drug discovery. Only a small percentage of the proposed drug candidates receive government approval and reach the market place. Unfavorable pharmacokinetic properties, poor bioavailability and efficacy, low solubility, adverse side effects and toxicity concerns account for many of the drug failures encountered in the pharmaceutical industry. Authors from several countries have contributed chapters detailing regulatory policies, pharmaceutical concerns and clinical practices in their respective countries with the expectation that the open exchange of scientific results and ideas presented in this book will lead to improved pharmaceutical products. BT - Toxicity and Drug Testing SP - Ch. 4 UR - https://doi.org/10.5772/18501 DO - 10.5772/18501 SN - PB - IntechOpen CY - Rijeka Y2 - 2019-11-14 ER -