TY - CHAP A1 - Hao-Chih Tai A2 - Ching-Fu Tu A3 - Tien-Shuh Yang A4 - Jang-Ming Lee A5 - San-Yuan Huang A6 - A7 - Bao-Tyan Wang ED1 - Shuji Miyagawa Y1 - 2012-02-03 PY - 2012 T1 - Function Measurements of HLA-II Transgenic Pigs for Xenotransplantation N2 - Accompanied by the advent of animal cloning, the technique of nuclear transfer produced alpha1,3-galactosyltransferase-knockout (Gal-KO) pigs in many institutes, including the ones in Japan, at the beginning of 21st Century. In addition, the controversy of the risks of PERV has gradually minimized, because of the fact that there are no cases of PERV infections reported in humans. Furthermore, a large clinical wave for islet allotransplantation resumed the interest of xenotransplantation, especially porcine islet transplantation and some exceptions. Clinical trials were done in many countries so far, such as Sweden, China, Mexico, USA (Inventory of Human Xenotransplantation Practices - IXA and HUG in collaboration with WHO). In addition, a new clinical trial was approved by the government, and resumed the porcine islet transplantation research in New Zealand two years ago. BT - Xenotransplantation SP - Ch. 4 UR - https://doi.org/10.5772/34018 DO - 10.5772/34018 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-07-24 ER -