TY - CHAP A1 - Hitomi Matsunari A2 - Masahito Watanabe A3 - Kazuhiro Umeyama A4 - Kazuaki Nakano A5 - Yuka Ikezawa A6 - Mayuko Kurome Barbara Kessler A7 - Eckhard Wolf A8 - Shuji Miyagawa A9 - Hiromitsu Nakauchi A10 - Hiroshi Nagashima ED1 - Shuji Miyagawa Y1 - 2012-02-03 PY - 2012 T1 - Cloning of Homozygous a1,3-Galactosyltransferase Gene Knock-Out Pigs by Somatic Cell Nuclear Transfer N2 - Accompanied by the advent of animal cloning, the technique of nuclear transfer produced alpha1,3-galactosyltransferase-knockout (Gal-KO) pigs in many institutes, including the ones in Japan, at the beginning of 21st Century. In addition, the controversy of the risks of PERV has gradually minimized, because of the fact that there are no cases of PERV infections reported in humans. Furthermore, a large clinical wave for islet allotransplantation resumed the interest of xenotransplantation, especially porcine islet transplantation and some exceptions. Clinical trials were done in many countries so far, such as Sweden, China, Mexico, USA (Inventory of Human Xenotransplantation Practices - IXA and HUG in collaboration with WHO). In addition, a new clinical trial was approved by the government, and resumed the porcine islet transplantation research in New Zealand two years ago. BT - Xenotransplantation SP - Ch. 3 UR - https://doi.org/10.5772/29267 DO - 10.5772/29267 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-09-23 ER -