TY - CHAP A1 - MichaƂ Rabijewski A2 - Lucyna Papierska ED1 - Raghvendra K. Dubey Y1 - 2012-02-08 PY - 2012 T1 - Osteoporosis in Men - A Crucial Role of Sex Hormones N2 - Sex Hormones not only regulate reproductive function, but they also play a prominent role in the biology and physiology of several organs/tissues and in the pathophysiology of several diseases. During the last two decades, the information on the mechanisms of action of sex hormones, such as estrogens and androgens, has rapidly evolved from the conventional nuclear receptor dependent mechanisms to include additional non-nuclear, non-genomic and receptor-independent mechanisms. This highlights the need to update the current knowledge on sex hormones and their mode of action. Increasing evidence that exogenous/epigenetic factors can influence sex hormone production and action highlights the need to update our knowledge on the mechanisms involved. This book provides a systematic and updated overview of the male/female sex-hormones and their impact in the biology and physiology of various organs. Additionally, the book discusses their positive and negative association with the pathophysiology of various diseases (e.g. osteoporosis, cardiovascular-disease, hypogonadism, reproduction, cancer) and their therapeutic potential. BT - Sex Hormones SP - Ch. 8 UR - https://doi.org/10.5772/28546 DO - 10.5772/28546 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-08-07 ER -